Evaluation hämodynamischer Effekte von Timolol, Dorzolamid und Latanoprost bei Patienten mit neu diagnostiziertem Offenwinkelglaukom

Purpose: Using scanning laser fluorescein angiography to compare the hemodynamic effect of timolol, dorzolamide and latanoprost in newly diagnosed patients with open angle glaucoma. Methods: 14 patients with newly diagnosed open angle glaucoma received randomley either timolol, dorzolamide or latanoprost for four weeks after baseline visit. After a complete ophthalmological examination scanning laser fluorescein angiography were performed. From these angiograms arteriovenous passage times (AVP) and peripapillary arterial and venous diameters were assessed by means of digital image processing. Results: Intraocular pressure (IOP) was significantly lowered by each drug compared to baseline visit (p<0.0001). Between the three groups there was no significant difference in lowering the IOP. Contrast sensitivity was significantly improved after dorzolamide instillation at 6 cycles per degree compared to timolol (p=0,04). No effect was seen in white- on-white or blue-on-yellow automated perimetry after either of the medications. AVP was significantly shortened after dorzolamide instillation (p=0.007) compared to baseline visit whereas neither timolol nor latanoprost resulted in a significant reduction. Peripapillary arterial and venous diameters remained unaffected by the antiglaukomatous medications. Conclusion: Dorzolamide showed a significant AVP reduction in newly diagnosed open angle glaucoma patients. None of the drugs led to a detectable effect on arterial and venous diameters. Ischemia is considered being a factor in the degenerative cascade of the glaucomatous optic neuropathy. Then increased perfusion might prove beneficial to slow disease progression.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2003

Author dc:creator

• Wolter, Pia

Contributors dc:contributor

• Arend, Kay Oliver

• info:eu-repo/classification/ddc/610
• Medizin
• Glaukom
• Timolol
• Latanoprost
• Dorzolamid
• Fluoreszenzangiographie
• arteriovenöse Passagezeit

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-120849%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:59031