Korrelation von Zytogenetik und Klinik bei 31 papillären Nierenzellkarzinomen

The present study examined in case of papillary renal cell carcinoma (pRCC) whether there consists a correlation between kind and number of the cytogenetic changes and clinical progress, in order to win conclusions of the prognostic relevance of the cytogenetic. Material and methods: Between 1988 and 1997 altogether 31 pRCC of 30 patients were cytogenetically analyzed by short time cultures. The histomorphologic grading oriented itself at the classification of Thoenes et al. (1991) and at the WHO classification for epithelial RCC (Mostofi 1997). In 24 cases the samples have been preparated by radical nephrectomies, in 6 cases by partial resection and in one case the tissue originated from a lymph node. The follow-up data ended in 2001. Results: The cytogenetic dressing showed that both primary and secondary aberrations were clearly presented.. The chromosomes 4 and 10 were involved in no case of the 31 pRCC. There has been no remarkable association of the tumor size and aberration of certain chromosomes. Some authors describe a correlation between trisomy 16 and a higher malignant tendency of the tumor. This could not be verified in this study. With two exceptions all patients with well differentiated pRCC showed complete remission independent from the tumor size. In one case a local lesion after enukleation was observed. Seven of the 30 patients died, 2 of them reliably because of the pRCC. Nine of the 30 patients developed a malignant second desease. Discussion: The aberrations followed a chronological sequence, but did not present a correlation between tumor-size, quantity or quality of the aberrations and the clinical progress. The difficulty to evaluate the progress consisted of the fact that the patients immediately after diagnosis have been treated by surgery. This examination did not demonstrate that the cytogenetic obtains prognostic relevance.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2002

Author dc:creator

• Dieckmann, Bettina Alexandra Felicitas

Contributors dc:contributor

• Füzesi, Budapest László

• info:eu-repo/classification/ddc/610
• Medizin
• pap. NZK

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-120560%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:58712