Zelluläre inflammatorische Reaktion und Keratan-Sulphat-Proteoglycan-Expression nach experimentellen Kompressionsverletzungen des Rückenmarks adulter Ratten

Following spinal cord injury of adult mammals there is only poor axonal regeneration. Animal experiments showed that there are neuronal and non-neuronal reasons for the limited axonal regeneration. In the last years, the role of the restricted inflammatory response, the deposition of putatively inhibitory proteoglycans and the composition of the extracellular matrix have been discussed. In this study, in an experimental model of spinal cord compression injury the inflammatory response and the expression of keratan sulphate proteoglycan (KSPG) and their relationship with axonal regeneration have been investigated immunohistochemically. A significant temporal correlation between regeneration and macrophage activation has become evident. Axonal regeneration is most intensive when macrophages are highly activated and stops when macrophages get inactivated. 21 and 28 days post operation, there is intensive KSPG-expression within the lesion site. No inverse spatial correlation between KSPG expression and axonal regeneration was detected, indicating that at least some axonal populations can tolerate the putatively inhibitory effect of KSPG. The identification of macrophage populations supporting regeneration could lead to a non-invasive therapeutic concept by means of the pharmacological manipulation of these cells.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2002

Author dc:creator

• Krautstrunk, Marlene

Contributors dc:contributor

• Nacimiento, Wilhelm

• info:eu-repo/classification/ddc/610
• Medizin

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-119137%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:57068